• IC values were obtained for

  2023-12-12

  

  IC50 values were obtained for an expanded version of the fragment library using the previously described mobility shift assay. Subsequently, Ki values were estimated from IC50 values to allow better comparison of the activity against targets which were measured at different substrate concentrations

• Phagosomes acquire some hydrolases early during their journe

  2023-12-12

  

  Phagosomes acquire some hydrolases early during their journey from the cell surface to lysosomes. An example for such hydrolase is cathepsin H which is most concentrated in the early phagosome at a pH of approximately 6.3 (Claus et al., 1998), the pH optimum of enzyme activity (Schwartz and Barrett,

• br Experimental procedures br Results br Discussion Major de

  2023-12-12

  

  Experimental procedures Results Discussion Major depressive disorder is among the leading causes of disability worldwide (Vos et al., 2015). One of the major causal or exacerbating factors of depression is long term stress or psychological trauma (Liu and Alloy, 2010). Dysregulation of the

• As regards LEPR Sun et al showed that the rs

  2023-12-12

  

  As regards LEPR, Sun et al. showed that the rs1137101-223A > G polymorphism influences the effectiveness of simvastatin on plasma HDL-C levels in CHD patients [35]. In accordance with the results of García-Bermúdez et al., however, no such an association exists between leptin rs2167270 (G > A) polym

• br Technical Note Fungal spoilage of dairy products

  2023-12-12

  

  Technical Note Fungal spoilage of dairy products remains a major concern for dairy manufacturers despite the use of preventive and control approaches, including the use of chemical preservatives. Among methods that are increasingly used by industries for microbial contaminant control, biopreserva

• br Functions essentially consisting in transport of substrat

  2023-12-12

  

  Functions essentially consisting in transport of substrates across plasma membranes Direct activation of neurotransmitter transporters elicits responses in neurons As previously mentioned (Section 2.1), nerve terminals handling classical transmitters possess transporters able to (re)capture se

• br Materials and Methods br Results br Discussion Voluminous

  2023-12-12

  

  Materials and Methods Results Discussion Voluminous literature is available describing the regulation of Edoxaban homeostasis by central and peripheral mechanisms in poultry [35,36]. However, the neuroendocrine mechanism(s) of photoperiod induced hypothalamic regulation of food intake and e

• In young animals the HT

  2023-12-12

  

  In young animals, the 5-HT2A Viroptic australia antagonist ketanserin, at relatively low concentrations, shifted 5-HT concentration-response curves rightward, suggesting a role for 5-HT2A receptors in mediating 5-HT-induced contractions of the ureter. The slopes of the ketanserin Schild plots for t

• Although the immobilization by histidine tag

  2023-12-12

  

  Although the immobilization by histidine tag exhibits effectiveness in oriented enzyme immobilization, it still faces some challenges [31]. On one hand, some unnecessary metal-binding proteins that interfere with the combination between the target protein and the supports or the additional interacti

• fluvastatin We have previously shown that the

  2023-12-12

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor fluvastatin (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insight i

• In this study we obtained the

  2023-12-11

  

  In this study, we obtained the absorbance and photoluminescence (PL) of O-propargyl-puromycin synthesis polymerized with various types of actin-binding proteins in order to probe the actin structures in situ without labeling. Both optical measurements have been useful in examining biomaterials such

• Introduction The cytoskeleton allows cells to establish main

  2023-12-11

  

  Introduction The cytoskeleton allows cells to establish, maintain and transform their shape. In neurons, these include cell differentiation, migration, polarization and development of their unique arborization. Axons are very thin (~1 μm), long (up to 1m) and highly branched (>95% of the plasma mem

• br Actin at presynapses br

  2023-12-11

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal SGX523 australia is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb

• br ACK inhibitors Since ACK activation is

  2023-12-11

  

  ACK1 inhibitors Since ACK1 activation is correlated with poor prognosis in various cancers, strong efforts are being directed by multiple groups towards developing highly potent and specific small molecule inhibitors targeting the ACK1 kinase. At least eight small molecule kinase inhibitors have

• Defining the multiple roles of autophagy in

  2023-12-11

  

  Defining the multiple roles of autophagy in stroke has been a rapidly evolving and exciting venue for translational research, with innovative products being applied from bench to bedside. Spanning pharmacological pathway manipulation and functional experimental validation, altered autophagy activati

14925 records 229/995 page Previous Next First page 上5页 226227228229230 下5页 Last page