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br Concluding remarks In this
2021-11-06
Concluding remarks In this small material of thirteen pituitary tumors of various kinds, we could not run statistical analysis. However, with a follow-up period of up to five years, we show that Disclosure Statement Acknowledgments Introduction Galanin is a 29/30-residue neuropeptide fo
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PIK-75 br Acknowledgements This study was supported by Natio
2021-11-06
Acknowledgements This study was supported by National Institutes of Health grant (R01GM104037), VA grant (BX002741), and Rutgers Busch grant. Nuclear receptor FXR is the master regulator of bile acids homeostasis The farnesoid X receptor (FXR) belongs to a family of proteins known as nuclear
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Several mechanisms have been suggested to underline the rele
2021-11-06
Several mechanisms have been suggested to underline the release of signalling molecules from astrocytes: reverse operation of glutamate transporters, volume-regulated anion channels, gap-junctional hemi channels, diffusional release through purinergic receptors and Ca2+-dependent exocytosis [2], [15
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br Methods br Results br Discussion TA TMA
2021-11-06
Methods Results Discussion TA-TMA is a severe complication for patients after HSCT. The pathogenesis of TA-TMA is unclear. Complement activation and endothelial cell injury may be involved in the pathogenesis of TA-TMA. Our previous investigations had demonstrated that plasma levels of C5b-
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br Acknowledgments Authors are thankful
2021-11-06
Acknowledgments Authors are thankful to the participants of the study for their cooperation. Financial support from Higher Education Commission (HEC) of Pakistan is highly acknowledged. AZ is supported by indigenous PhD fellowship from HEC. Indigenous PhD Fellowship for 5k Scholars batch 2 PIN NO
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Whereas Sororin is dispensable in the absence of Wapl overex
2021-11-05
Whereas Sororin is dispensable in the absence of Wapl [14], overexpressed Haspin only partly supports cohesion in Sororin-depleted cells. Thus, although Haspin and Sororin have functional similarities, they are not fully redundant at the centromere. Haspin may have a mitosis-specific role in maintai
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Phosphoramidon Disodium Salt Studies dealing with the effect
2021-11-05
Studies dealing with the effects of ischemia on EAATs have been previously reported, but some discrepancies in literature appear between them probably as a consequence of the different models, species, time of reperfusion after ischemia and age of the animals. Thus, in human, Phosphoramidon Disodium
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Similarly both neofunctionalization and subfunctionalization
2021-11-05
Similarly, both neofunctionalization and subfunctionalization likely occurred for the duplicated proglucagon genes. The change in function of GLP-1 would be a neofunctionalization, however in this case it acquired a redundant function – a function that largely overlaps with glucagon effects in the l
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br Role of ghrelin in reward and addiction In
2021-11-05
Role of ghrelin in reward and addiction In addition to its well-known effects on 5153 homeostasis regulation at the hypothalamic level [reviews in (Al Massadi et al., 2017, Muller et al., 2015)], ghrelin also has the ability to increase food motivation acting on hypothalamic and extra-hypothalam
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br Materials and methods br
2021-11-05
Materials and methods Results Discussion Zn2+ is an extremely abundant transition metal in the synaptic vesicles of hippocampal glutamatergic mossy fibers and remains a key factor in the modulation of neuronal plasticity (Assaf and Chung, 1984). Disruption of Zn2+ homeostasis is associated
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Target regulated the formation of G quadruplex was used here
2021-11-05
Target-regulated the formation of G-quadruplex was used here to “kill two PPM-18 with one stone” for the detection of melamine and I− with one probe DNA. G-quadruplexes are higher-order structures formed from G-rich oligonucleotides through the stacking of planar G-tetrads [43,44]. They have been e
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Piroxicam belongs to the oxicam family of NSAIDs and
2021-11-05
Piroxicam belongs to the oxicam family of NSAIDs and a special attention has been drawn to this drug because of its multifunctional potential [5], [27], [28]. Chemically, piroxicam (4-hydroxy-2-methyl-N-2-pyrimidyl-2H-1,2-benzothiazine-3-carboxyamide) is an enolic cytokine inhibitors with a size co
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Free fatty acids FFAs which are obtained from dietary
2021-11-05
Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty mi2 receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Short chain F
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In humans mutations in KDM A KDM B and KDM
2021-11-05
In humans, mutations in KDM5A, KDM5B, and KDM5C are found in patients with ID, implicating KDM5-regulated transcription in the development or activity of neuronal tissues (Vallianatos and Iwase, 2015). KDM5D is Y-linked, and its role in cognition remains uncharacterized. Mutations in KDM5C are the m
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The rationale for developing HDACi as anticancer agents was
2021-11-04
The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and BAY 57-1293 arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of hematolo
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