• molarity conversion Western blotting and flow cytometry

  2021-04-26

  

  Western blotting and flow cytometry was employed to assess the DNA-PK inhibition of LTU28 and LTU31 in combination with radiation. It has been previously reported that phosphorylation of DNA-PKcs at the Thr2609 cluster plays an important role in DSB repair and resistance to radiation (Ding et al., 2

• Multiple sequence alignment of the proteins in the DGAT

  2021-04-26

  

  Multiple sequence alignment of the proteins in the DGAT1 sub-family shows that there are about 41 conserved amino regulator of g protein signaling residues distributed over seven sequence motifs [74]. Unlike DGAT2, a large number of DGAT1 residues, including a majority of the conserved residues, ar

• Several RNA BPs like the

  2021-04-26

  

  Several RNA-BPs, like the ELAV protein family member HuR, tristetraprolin (TTP) or the KH-type splicing regulatory protein (KSRP) have been shown to interact with these AREs and thereby lead to stabilization or destabilization of the mRNA [5]. Control of nucleocytoplasmic mRNA export is also very i

• br Results br Discussion br Experimental Procedures br Autho

  2021-04-26

  

  Results Discussion Experimental Procedures Author Contributions Acknowledgments Introduction Excitatory synaptic transmission within the brain is largely mediated by ionotropic glutamate receptors. At glutamatergic synapses, α-amino-3-hydroxy-5-methylisoxazole-4-proprionic AUY922 m

• Neuroinflammation is the one of

  2021-04-26

  

  Neuroinflammation is the one of the emerging causal factors contributing to these cognitive deficits. Therefore, we further tested the hypothesis that neuroinflammation is a key component contributing to the progression of spatial memory deficits during HH. Spatial memory deficits were observed afte

• resveratrol Materials and methods br Results br Discussion M

  2021-04-26

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino resveratrol for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the existi

• br Experimental br Declaration of interest br

  2021-04-26

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR beta adrenergic receptors library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compoun

• These data indicate that in the context

  2021-04-26

  

  These data indicate that, in the context of the N-terminal 42 amino acids of p53, threonine 18 is a substrate for phosphorylation by CK1 as mediated by prior phosphorylation of serine 15. To determine whether this is a property of full length p53, GST-p53 fusion proteins comprising the full length p

• br Acetylcholinesterase and cholinergic signaling The

  2021-04-26

  

  Acetylcholinesterase and cholinergic signaling The concept of a synapse between a neuron and an innervated cell, and the receptors that mediated their interaction, was developed by Bernard, Ehrlich, Sherrington, Langley and others (see [7], [8], [9]. It was long debated whether transmission of ne

• The genetic basis of resistance to

  2021-04-26

  

  The genetic basis of resistance to dieldrin has been described for several insect species as a mutation in the transmembrane domain II of the GABA-Cl or rdl (resistance to dieldrin) gene (ffrench-Constant et al., 2004; Bass et al., 2004; Du et al., 2005). A mutation in the GABA-Cl gene was found at

• In the present study we investigated the effect of

  2021-04-26

  

  In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G

• Our earlier experimental studies showed neutral i e non prol

  2021-04-26

  

  Our earlier experimental studies showed "neutral", i.e. non-proliferative, effects of progesterone but a large increase in proliferation using certain progestins; however, this was only in the presence of PGRMC1 [[13], [14], [15], [16], [17], [18], [19]]. The next step was to investigate whether thi

• br Conclusion br Acknowledgments This work was

  2021-04-26

  

  Conclusion Acknowledgments This work was supported by Progetto PON - “Ricerca e Competitività 2007–2013” - PON01_01802: “Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redox-sensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e lor

• br Disclosures br Acknowledgements This work was

  2021-04-26

  

  Disclosures Acknowledgements This work was supported by the Natural Science Foundation of China (No. 81560587); the Fok Ying-Tong Education Foundation of China (No. 151107), the basic ability promotion project for young and middle-aged teachers in Universities in Guangxi (No. 2018KY1146) and t

• br Introduction Esophageal squamous cell carcinoma ESCC is o

  2021-04-26

  

  Introduction Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer in East Asia and is a leading cause of cancer-related death worldwide.1, 2 Surgery is widely used for treatment in localized disease, where it can provide definitive management and potential cure. Tre

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