• br Advanced Glycation Endproducts As glucose levels rise

  2021-10-11

  

  Advanced Glycation Endproducts As glucose levels rise within sensory neurons as a result of hyperglycemia, normal metabolic pathways become overwhelmed and excess glucose is shunted into other ancillary pathways that, under these conditions, become damaging. One consequence of hyperglycemia is th

• br Ca influx through glutamate

  2021-10-11

  

  Ca2+ influx through glutamate receptors is thought to play a critical role in synaptogenesis and in the formation of neuronal circuitry during early development[45]. Because AMPA receptors might contribute to these processes, particularly at times and in cells in which NMDA receptor expression is

• Compound was obtained as a yellow

  2021-10-11

  

  Compound was obtained as a yellow crystal (acetone). And the molecular formula of was established as CHO on the basis of a quasi-molecular ion at / 331.0799 [M+H] (calcd. for 331.0818) in its HR-ESI-MS. Compound showed H and C NMR similar to those of PF-01367338 receptor . However, The H NMR spe

• br Materials and methods br Results

  2021-10-11

  

  Materials and methods Results Discussion Our liver-specific Gck (−/−) mice and another line of liver-specific mice [13] exhibited impaired glucose tolerance. Furthermore, both knockout mice showed decreased hepatic glycogen content and reduced Pklr and Fas gene TL32711 australia in the liv

• Despite potent biological actions the native hormone undergo

  2021-10-11

  

  Despite potent biological actions, the native hormone undergoes degradation by the enzyme dipeptidylpeptidase-IV (DPP-IV) [17] and is rapidly cleared from the bloodstream by renal filtration [18]. One such approach to prolong the biological half-life of GIP is through conjugation with a polyethylene

• Immunohistochemistry analysis shown ghrelin and GHSR

  2021-10-11

  

  Immunohistochemistry analysis shown ghrelin and GHSR-1a immunostaining was located in the epithelial cells of Biotin-HPDP and ducts throughout the lactation, strong immunoreactive cells were detected in L30, L60 and L120 stage. The distribution of ghrelin has been shown in many tissues, including m

• Cy7 NHS ester (non-sulfonated) So in this study our results

  2021-10-11

  

  So in this Cy7 NHS ester (non-sulfonated) study, our results firstly demonstrated that i.c.v. injection of ghrelin(1–7)-NH2 played a significant role in the modulation of the acute heat pain at the supraspinal level in mice. Our results showed that i.c.v. injection of ghrelin(1–7)-NH2 produced dose

• The activation of the ERK pathway participates in the

  2021-10-11

  

  The activation of the ERK pathway participates in the transmission of pain signaling by sensitizing primary afferents (Ji et al., 2009, Lai et al., 2011). Thus, the blockade of ERK activation in the primary sensory beta-Nicotinamide mononucleotide mg can reduce the mechanical hypersensitivity and t

• The sexual dimorphism in dlGALR a

  2021-10-11

  

  The sexual dimorphism in dlGALR1a and dlGALR1b receptors found in the gonads of adult fish led us to hypothesize that the gene expression difference between female and males might be attributed to the differences in steroid production between female and male gonads. Interestingly we have found that

• However protection against kainic acid induced injury

  2021-10-11

  

  However, protection against kainic acid-induced injury was not found by Lin et al. (2003) in the rats with AAV-GAL vector-mediated galanin overexpression, even though these animals, as mentioned earlier, exhibited attenuated of seizure severity. Although the reason for the controversy between the st

• br Introduction Farnesoid X receptor FXR is a

  2021-10-09

  

  Introduction Farnesoid X receptor (FXR) is a bile 2 nbdg regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (OSTα) that are in

• The activation of GPR FFA signaling

  2021-10-09

  

  The activation of GPR40/FFA1 signaling triggers the PLC/PIP2 signaling pathway and results in Ca2+ release from the endoplasmic reticulum (ER). Increased Ca2+ levels may lead to activation of different protein kinases, such as Ca2+/calmodulin-dependent protein kinase type IV, Akt, extracellular sign

• br Acknowledgements We thank Dr

  2021-10-09

  

  Acknowledgements We thank Dr. Bhushan Nagar and Dr. Albert Berghuis for access to the X-ray diffraction machine at McGill University. We also thank Dr. Manon Couture and Dr. Steve Charette at Université Laval for access to scientific equipment. Funding for this research was provided by Discovery

• Computational approaches such as docking and classical molec

  2021-10-09

  

  Computational approaches such as docking and classical molecular dynamics (MD) are now commonly used to study the structure and dynamics of proteins as well as associated protein-ligand interactions [12]. A fundamental requirement of MD in order to accurately determine the behavior of a protein over

• br Conflict of interest br Funding br Introduction Heme is

  2021-10-09

  

  Conflict of interest Funding Introduction Heme is an essential molecule for cellular metabolism involving oxygen and electron transfer [1]. However, free heme is a potent pro-oxidant that catalyzes the generation of reactive oxygen species (ROS) leading to cellular damage [2]. Heme oxygenas

15098 records 574/1007 page Previous Next First page 上5页 571572573574575 下5页 Last page